106 Comparison Of Two One-Week Triple Recommended Therapy For Eradication Of Helicobacter Pylori Nhfection

Author(s): 
PALKA Malgorzata, ZWOLINSKA-WCISLO Malgorzata, WINDAK Adam, KLICHZKA Alicja. E-mail: mmpalka@cyf-kr.edu.pl
Text: 
Introduction:
Infection of Helicobacter (H.) pylori is a major cause of many gastroduodenal diseases. One-week triple therapy has become the standard of care. The European Society for Primary Care Gastroenterology (ESPCG) has developed guidance for the primary care physician in Europe. Two different one-week regiments were recommended.
Aims: The aim of the study was to assess effectiveness of triple therapy including metronidazole in Poland, where as high as 70% resistance to metronidazole was reported.
Methods: Sixty-two patients (37 women) with peptic ulcer diseases and H. pylori infection were included in the study. Patients were randomly selected to receive omeprazole 2x20 mg/day, clarithromycin 2x 500 mg/day, amoxicillin 2x1000 mg/day for 7 days (group A; n=30) or omeprazole 2x20 mg/day, clarithromycin 2x 500 mg/day, metronidazole 2x500 mg/day for 7 days (group B; n=30) H. Pylori status was determinate by CLO test during the gastroscopy before the treatment and by 13C UBT 4 weeks after therapy.
Results: Sixty patients completed the study. H. pylori infection was eradicated in 94% of patients in group A and 89% of patients in group B. Side effects, usually minor, were recorded but therapy was discontinued for only two patients in group A.
Conclusions.
Both regiments obtain a high H. pylori eradication rate. It seems that therapy with metronidazole can be used in Poland. Further studies are needed to assess influence of clarithromycin on lower rate of metronidazole resistance.
Literature: 
106 COMPARISON OF TWO ONE-WEEK TRIPLE RECOMMENDED THERAPY FOR ERADICATION OF HELICOBACTER PYLORI NHFECTION