993 (Po) Is Insulin Pumps The Ultimate Therapy For Diabetes Type I?

Conference: 
Author(s): 
A. Kamaratos1, I. Lentzas1, L. Salvanos1, A. Alevizos1, A. Katsanaki1, P. Daskalakis2, G. Belos1, E. Koutsoukou1, A. Mariolis2, A. Melidonis1
1Diabetes Centre of Tzanio General Hospital, Piraeus,
2Health Centre of Vyronas, Greece
Text: 
BACKGROUND/AIM:
Many studies have proved the superiority of the continuous subcutaneous infusion of insulin compared with the intensive regimens of multiple subcutaneous insulin injections. To estimate the effectiveness of the continuous subcutaneous insulin infusion on glycaemic and metabolic control, as well as the incidence of complications in type 1 diabetics after 1 and 2-year follow-up.
METHODS:
The study included 16 patients who were administered intensive insulin regimens without acceptable glycaemic and metabolic control. The parameters that were determined at the beginning, before the administration of insulin infusion pump and after the lapse of one and two years, were HbA1c, cholesterol, aminotransferases, triglycerides, HDL, total protein in 24hour urine collection, blood pressure and body weight (WHR), the number of hypoglycaemic episodes, the required insulin dose and the self-estimation of quality of life. Finally, diabetic complications were determined. Statistical analysis was performed by paired T test, Mac-Nemar.
RESULTS:
There were no significant statistical differences during the last year period of observation in the following parameters: mean values of HbA1c: 7.98% vs. 7.28% (p:NS), fasting glucose: 201vs 151 mg/dL, cholesterol: 214 vs. 201.25 mg/dL, HDL: 68 vs. 72, SGOT: 19.8 vs. 15.4, SGPT: 29 vs. 15.2, total protein in 24hour urine: 112.4 mg/24 vs. 108, correspondingly. Triglycerides level and hypoglycaemic episodes did not present any SS (85.38 vs 103 mg/dL, 2.3 vs. 3, correspondingly). Insulin units increased from 39.5 to 45 IU, p=0.083). No alterations in quality of life or in the incidence of diabetic complications were observed.
CONCLUSION:
In the second year no significant statistical changes in metabolic and glycaemic control were observed, however an increase in administered insulin units was necessary. Gradual deterioration of glycaemic control during the second year of insulin pump use was observed. More self-monitoring, intensified treatment and psychological support may be required.
Literature: 
993 (PO) IS INSULIN PUMPS THE ULTIMATE THERAPY FOR DIABETES TYPE I?