OP-052 : Characteristics of persons with functional syndromes within a sample with psychopathology

Henriette E. van der Horst, Sophie A. Vreeburg, Brenda W. Penninx, Netherlands
In primary care functional syndromes (chronic fatigue syndrome (CFS), fibromyalgia (FM), irritable bowel syndrome (IBS)) often co-occur with depressive and anxiety symptoms/disorders, leading to serious disability. To explore the relationship between depression/anxiety and functional syndromes, we examined characteristics of persons with and without a functional syndrome in a sample with lifetime psychopathology.

We used data from persons with lifetime CIDI-diagnoses of depression and/or anxiety disorders (n=1767) from a cohort consisting of community, primary care and specialized mental health care samples (Netherlands Study of Depression and Anxiety). 231 of these reported having CFS (n=32), FM (n=47) and/or IBS (n=176). We analysed socio-demographics, health factors (e.g. smoking, psycho-active medication), psychopathological symptom profile (e.g. severity, somatic symptoms) and disability (WHO-DAS) and salivary cortisol samples (awakening, and after 30, 45 and 60 minutes).

Persons with a functional syndrome were more often women (81.4 vs 65.2%, p

Within this sample persons with a functional syndrome form a more severely ill and impaired subgroup. In addition, CFS was associated with a lower CAR, possibly indicating exhaustion of the HPA axis. These differences might be relevant for (risk) identification and treatment of these patients.