OP-052 : Characteristics of persons with functional syndromes within a sample with psychopathology

Author(s): 
Henriette E. van der Horst, Sophie A. Vreeburg, Brenda W. Penninx, Netherlands
Text: 
In primary care functional syndromes (chronic fatigue syndrome (CFS), fibromyalgia (FM), irritable bowel syndrome (IBS)) often co-occur with depressive and anxiety symptoms/disorders, leading to serious disability. To explore the relationship between depression/anxiety and functional syndromes, we examined characteristics of persons with and without a functional syndrome in a sample with lifetime psychopathology.

We used data from persons with lifetime CIDI-diagnoses of depression and/or anxiety disorders (n=1767) from a cohort consisting of community, primary care and specialized mental health care samples (Netherlands Study of Depression and Anxiety). 231 of these reported having CFS (n=32), FM (n=47) and/or IBS (n=176). We analysed socio-demographics, health factors (e.g. smoking, psycho-active medication), psychopathological symptom profile (e.g. severity, somatic symptoms) and disability (WHO-DAS) and salivary cortisol samples (awakening, and after 30, 45 and 60 minutes).

Persons with a functional syndrome were more often women (81.4 vs 65.2%, p

Within this sample persons with a functional syndrome form a more severely ill and impaired subgroup. In addition, CFS was associated with a lower CAR, possibly indicating exhaustion of the HPA axis. These differences might be relevant for (risk) identification and treatment of these patients.