Po1106 Treatment Of Hypertension In Patients With Chronic Renal Failure

Leposava Bunjak1
1Health Centre Zvezdara, Belgrade
Aims and purpose: Hypertension is one of the most frequent causes of chronic renal failure. Many clinical studies have shown that blockade of angiotensin can postpone the end stage of renal failure and also prevent chronic renal disease in risk group. The aim was to assess the frequency of the occurrence of renal failure markers in two groups of patients involved in research study.
Design and method: Prospective research anticipate 158 patients age 61,69,9 with hypertension and chronic renal failure (CRF) over a 12 month period. The research focused on hypertensive patients not treated with angiotensin – converting enzyme (ACE) – first group, and hypertensive patients treated with ACE-second group. As only 16 patients involved in research study, was not treated with ACE, the second group of 16 patients was randomly selected from the remaining patients involved in study. There was no difference in age, sex, arterial pressures values and duration of hypertension and CRF between two groups.
Results: The mean value of serum creatine level in the group of patients not treated with ACE was 812.mol/l and that was significantly higher than in patients treated with ACE whose serum creatine level was 746.mol/l. In patients not treated with ACE glomerular filtration rate (GFR), calculated with MDRD formula, was 7316 ml/min 1.73m2. In group of patients treated with ACE GFR was 8410ml/min 1,73m2 (pConclusion: Use of ACE in patients with hypertension and CRF had better control GFR than patients treated with other antihypertensive drugs. ACE can go under the name of “drugs for kidney diseases“ and can be recommended for prevention of CRF even in patients with out hypertension but who are at the risk of that disease.
chronic renal failure; hypertension; angiotensin converting enzyme;