Pp-247 The Characteristic Features, Homocysteine, Vitamin B12 And Folic Acid Levels Of Individuals With Metabolic Syndromes

Author(s): 
Kamile Marakoglu, Selma Civi, Ruhusen Kutlu
Selcuk University, Meram Medical Faculty, Department of Family Medicine, Konya, Turkey
Text: 
Objective: In this study, we aimed to determine the prevalence of Metabolic Syndrome (MS) and to evaluate several biochemical parameters in the cases examined at the polyclinic of Family Medicine.
Methods: This descriptive and cross-sectional study was carried out on 7 61 patients who applied to our clinic between 2006 February and 2008 February. In order to establish MS diagnosis, at least three of the diagnosis criteria suggested by International Diabetes Federation (IDF) were accepted as normal. [blood pressure 2:130/85 mmHg (or antihypertensive drug use); starvation plasma glucose ? 100 mg/dL (or antidiabetic drug use); starvation triglyceride ?150 mg/dL; HDL cholesterol 94cm (male) or>80 cm (female)]. Homocysteine, vitamin B12 and folic acid levels of these patients were evaluated.
Results: Of the 761 cases included in the study, %42.4(n=323) were man and %57.6(n=438) were women. MS criteria were found in %42.2(n=321) of the cases. The prevalence of MS in man (%50.2) was higher than in women (%36.3)(p=0.000). MS frequency among the illiterate (%67.4) was higher than the educated and literate(p=0.000). The mean age of the cases with MS(48.99±1 l.56) was higher than the cases without MS(40.59±13.19)(p=0.010). A chronic disease existence was more in the MS cases (%61.9) than the cases without · MS (%38.1)(p=0.000). While MS prevalence in the smokers (%39.6) was lower than in the cases who quitted smoking (%41.5) and non-smokers (%44.0), this state was not statistically significant (p=0.521 ). The average of homocysteine in the MS cases ( 15 .24±9.11) was higher than the cases without MS (13.63±5.4)(p=0.000). The mean of vitamin B12 in MS cases (253.3±114.3) was not statistically different from the cases without MS (255.0±98.3)(p=0.206). The average of folic acid in MS cases (7.38±4.08) was not significantly different from the cases without MS (7.35±3.59)(p=0.927).
Conclusion: High homocysteine level is related to MS. MS and high homocysteine level is known to increase risks for cardiovascular disease.
Literature: 
PP-247
THE CHARACTERISTIC FEATURES, HOMOCYSTEINE, VITAMIN B12 AND FOLIC ACID LEVELS OF INDIVIDUALS WITH METABOLIC SYNDROMES