USE OF HBA1C IN THE DIAGNOSIS OF TYPE 2 DIABETES IN HIGH RISK GROUP ATTENDING KLINIK RAWATAN KELUARGA, UNIVERSITI SAINS MALAYSIA

Author(s): 
ADIBAH HI 1, HASNI I 1, SHAIFUL BI 3, ET AL
1 Universiti Sains Malaysia, Malaysia
Text: 
BACKGROUND: For many years diagnosis of Diabetes Mellitus has depended primarily on results of Oral Glucose Tolerance Test (OGTT). The OGTT is the gold standard for diagnosing type 2 diabetes mellitus but it has limited use for mass screening, due to inconvenient and requires a great deal of patient cooperation. To improve patient compliance with testing, use of HbA1c to diagnose diabetes has been suggested. The study aims to evaluate the use of HbA1c as a diagnostic test for diabetes in high risk groups attending Klinik Rawatan Keluarga, USM.
METHODS: A cross-sectional study in which OGTT and HbA1c level were performed in 402 asymptomatic high risk subjects with capillary blood glucose 2:5.6 mmol/L.
RESULTS: The mean age and body mass index for study sample were 51.6 ア 9.2 and 26.8 ア 4.8 respectively. The mean of FPG level was 5.6 ア 2.2 mmol/ L, mean for 2HPP level was 9.6 ア 5.3 mmol/L and mean for HbA1c was 6.0 ア 1.5%. Of 402 patients, 45.3% (n=182) was diagnosed as normal glucose tolerance, 22.6% (n=91) had impaired glucose tolerance /impaired fasting glucose and 32.1 % (n=129) had diabetes mellitus. Patients with abnormal glucose tolerance had a higher percentage of HbA1c than subjects with normal glucose tolerance (pCONCLUSION: HbA1c measurement in high risk group of patients is a convenient alternative to oral glucose tolerance test for diagnosis of Type 2 Diabetes Mellitus.